Luliconazole cream is an antifungal medication used to treat common skin infections caused by fungus or yeast. It is available by prescription only. Primary uses Luliconazole is effective against a broad range of fungi, including Trichophyton rubrum and Epidermophyton floccosum, which are responsible for several types of tinea infections. It is commonly used for: Athlete's foot (tinea pedis): A fungal infection of the feet, typically between the toes. Jock itch (tinea cruris): A fungal infection affecting the groin and buttocks. Ringworm (tinea corporis): A fungal skin infection that can appear on various parts of the body. How it works Luliconazole belongs to a class of medications called azole antifungals. It works by inhibiting an enzyme in the fungus called lanosterol demethylase. This enzyme is necessary for the production of ergosterol, a vital component of the fungal cell membrane. By disrupting the fungal cell membrane, luliconazole kills the fungus and clears the infection. Common side effects Luliconazole is generally well-tolerated, but some people may experience mild side effects localized to the application site. These can include: Irritation Itching Redness or burning sensation Skin peeling or dryness Important safety information For external use only: The cream should not be taken by mouth and direct contact with the eyes should be avoided. Allergic reactions: Although rare, seek emergency medical help if you experience signs of a severe allergic reaction, such as swelling of the face, lips, or tongue; trouble breathing; or a severe rash. Medical advice: Always use luliconazole exactly as your doctor prescribes. Inform your doctor about any pre-existing medical conditions, allergies, and other medications you are taking.